Firewire is the choice of audio professionals and the manufacturers of studio-aimed interfaces. It is said to stream more data more consistently. If you are intending to set up a home studio, recording and mixing multi-channel, then the difference might matter.
It was the interface of choice for handycams. Mine (bought about 2003) uses it. Because of this, even if I only use the thing once in a year (or five: it was one of my money wasters) I need that firewire interface on the PC. Of course, firewire PCI cards are easily available.
(where did domestic handycams go next/now? I have no idea. hdmi? But a handycam needs a 2-way interface)
Anyway, firewire is available on many PC motherboards. If you have it, it is
yetanotherchoice in the matter of getting sound out of your pc. Don't worry about Windows "supporting" it, it does. Think of all those handycams out there! If your firewire audio interface comes with Windows drivers, that's all you need to know. There is
some kit (eg Apogee), that looks mouthwatering, but is made for the MacMarket and
will not run under Windows. But, of course, anyone buying anything for their PC is going to check the hardware/software supported section of the specs first, right?

**
Has the audio interface world even
noticed USB3.0 yet? I don't think so. Can't blame it, because nobody else of the pc peripherals market has much noticed it yet either. External drives and thumb drives come in drips and drabs...
If I had the budget, I'd find the oldest working PC with a PCI bus and no fan on the CPU (586? 486?), put a Lynx or RME card in it, load WinXP and foobar, and enjoy the
analogue out*. Mind you, I'd probably have to upgrade the amp and speakers to do it justice. As it is, I can't connect the PC directly to the stereo, don't have the furniture arranged for proper hifi listening --- and my Squeezebox Duet will do nicely.
If I had the budget... to experiment with all the kit I'd like to play with, just for fun, then I'd have the house and the room and all too
*then I'd check with Linux, which can generally be trusted to do almost anything better than Windows, with the important exception of driving uncommon hardware.
** Oh
YEAH? And guess who didn't notice a higher revision number for a server OS , and that the company's major accounts package did not support that revision, and spent about twenty thousand GBP on the server? Well, I was sooooo lucky. 'not supported' doesn't necessarily mean 'won't work.' It worked very well. Expensive mistakes of our time. Well,
my time
